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Major affective disorder 6(MAFD6)

MedGen UID:
372673
•Concept ID:
C1970945
•
Mental or Behavioral Dysfunction
Synonym: MAFD6
 
Monarch Initiative: MONDO:0012686
OMIM®: 611536

Professional guidelines

PubMed

Diagnosis and Treatment of Bipolar Disorder: A Review.
Nierenberg AA, Agustini B, Köhler-Forsberg O, Cusin C, Katz D, Sylvia LG, Peters A, Berk M
JAMA 2023 Oct 10;330(14):1370-1380. doi: 10.1001/jama.2023.18588. PMID: 37815563
Depression in the Primary Care Setting.
Park LT, Zarate CA Jr
N Engl J Med 2019 Feb 7;380(6):559-568. doi: 10.1056/NEJMcp1712493. PMID: 30726688Free PMC Article
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments.
Kennedy SH, Lam RW, McIntyre RS, Tourjman SV, Bhat V, Blier P, Hasnain M, Jollant F, Levitt AJ, MacQueen GM, McInerney SJ, McIntosh D, Milev RV, Müller DJ, Parikh SV, Pearson NL, Ravindran AV, Uher R; CANMAT Depression Work Group
Can J Psychiatry 2016 Sep;61(9):540-60. Epub 2016 Aug 2 doi: 10.1177/0706743716659417. PMID: 27486148Free PMC Article

Curated

UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

Recent clinical studies

Etiology

Altered serum TNF-α and MCP-4 levels are associated with the pathophysiology of major depressive disorder: A case-control study results.
Nayem J, Sarker R, Roknuzzaman ASM, Qusar MMAS, Raihan SZ, Islam MR, Mahmud ZA
PLoS One 2023;18(11):e0294288. Epub 2023 Nov 15 doi: 10.1371/journal.pone.0294288. PMID: 37967104Free PMC Article
Rapid improvements and subsequent effects in major depressive disorder patients with somatic pain using rTMS combined with sertraline.
Sun Y, Lei F, Zou K, Zheng Z
Sci Rep 2023 Oct 20;13(1):17973. doi: 10.1038/s41598-023-44887-w. PMID: 37863972Free PMC Article
Diagnostic Specificity and Association With Cognition of Molecular Alterations in Prefrontal Somatostatin Neurons in Schizophrenia.
Dienel SJ, Dowling KF, Barile Z, Bazmi HH, Liu A, Vespoli JC, Fish KN, Lewis DA
JAMA Psychiatry 2023 Dec 1;80(12):1235-1245. doi: 10.1001/jamapsychiatry.2023.2972. PMID: 37647039Free PMC Article
Efficacy and safety of lamotrigine in pediatric mood disorders: A systematic review.
Kumar R, Garzon J, Yuruk D, Hassett LC, Saliba M, Ozger C, Oztosun C, Ahern K, Athreya AP, Singh B, Croarkin PE, Vande Voort JL
Acta Psychiatr Scand 2023 Mar;147(3):248-256. Epub 2022 Sep 21 doi: 10.1111/acps.13500. PMID: 36086813
Having versus not having social interactions in patients diagnosed with depression or social phobia and controls.
Villanueva J, Meyer AH, Mikoteit T, Hoyer J, Imboden C, Bader K, Hatzinger M, Lieb R, Gloster AT
PLoS One 2021;16(4):e0249765. Epub 2021 Apr 14 doi: 10.1371/journal.pone.0249765. PMID: 33852620Free PMC Article

Diagnosis

Use of Lysergic Acid Diethylamide by Major Depression Status.
Walsh CA, Gorfinkel L, Shmulewitz D, Stohl M, Hasin DS
JAMA Psychiatry 2024 Jan 1;81(1):89-96. doi: 10.1001/jamapsychiatry.2023.3867. PMID: 37819655Free PMC Article
Altered serum TNF-α and MCP-4 levels are associated with the pathophysiology of major depressive disorder: A case-control study results.
Nayem J, Sarker R, Roknuzzaman ASM, Qusar MMAS, Raihan SZ, Islam MR, Mahmud ZA
PLoS One 2023;18(11):e0294288. Epub 2023 Nov 15 doi: 10.1371/journal.pone.0294288. PMID: 37967104Free PMC Article
Preclinical models of treatment-resistant depression: challenges and perspectives.
Kolasa M, Faron-Górecka A
Pharmacol Rep 2023 Dec;75(6):1326-1340. Epub 2023 Oct 26 doi: 10.1007/s43440-023-00542-9. PMID: 37882914Free PMC Article
Diagnostic Specificity and Association With Cognition of Molecular Alterations in Prefrontal Somatostatin Neurons in Schizophrenia.
Dienel SJ, Dowling KF, Barile Z, Bazmi HH, Liu A, Vespoli JC, Fish KN, Lewis DA
JAMA Psychiatry 2023 Dec 1;80(12):1235-1245. doi: 10.1001/jamapsychiatry.2023.2972. PMID: 37647039Free PMC Article
Having versus not having social interactions in patients diagnosed with depression or social phobia and controls.
Villanueva J, Meyer AH, Mikoteit T, Hoyer J, Imboden C, Bader K, Hatzinger M, Lieb R, Gloster AT
PLoS One 2021;16(4):e0249765. Epub 2021 Apr 14 doi: 10.1371/journal.pone.0249765. PMID: 33852620Free PMC Article

Therapy

Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin.
Rosenblat JD, Meshkat S, Doyle Z, Kaczmarek E, Brudner RM, Kratiuk K, Mansur RB, Schulz-Quach C, Sethi R, Abate A, Ali S, Bawks J, Blainey MG, Brietzke E, Cronin V, Danilewitz J, Dhawan S, Di Fonzo A, Di Fonzo M, Drzadzewski P, Dunlop W, Fiszter H, Gomes FA, Grewal S, Leon-Carlyle M, McCallum M, Mofidi N, Offman H, Riva-Cambrin J, Schmidt J, Smolkin M, Quinn JM, Zumrova A, Marlborough M, McIntyre RS
Med 2024 Mar 8;5(3):190-200.e5. Epub 2024 Feb 14 doi: 10.1016/j.medj.2024.01.005. PMID: 38359838
Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Do A, Li VW, Huang S, Michalak EE, Tam EM, Chakrabarty T, Yatham LN, Lam RW
Can J Psychiatry 2022 Oct;67(10):745-754. Epub 2022 May 6 doi: 10.1177/07067437221097903. PMID: 35522196Free PMC Article
Prognosis and improved outcomes in major depression: a review.
Kraus C, Kadriu B, Lanzenberger R, Zarate CA Jr, Kasper S
Transl Psychiatry 2019 Apr 3;9(1):127. doi: 10.1038/s41398-019-0460-3. PMID: 30944309Free PMC Article
Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis.
Mutz J, Vipulananthan V, Carter B, Hurlemann R, Fu CHY, Young AH
BMJ 2019 Mar 27;364:l1079. doi: 10.1136/bmj.l1079. PMID: 30917990Free PMC Article
Depression in the Primary Care Setting.
Park LT, Zarate CA Jr
N Engl J Med 2019 Feb 7;380(6):559-568. doi: 10.1056/NEJMcp1712493. PMID: 30726688Free PMC Article

Prognosis

Self-stigma and bipolar disorder: A systematic review and best-evidence synthesis.
Favre S, Richard-Lepouriel H
J Affect Disord 2023 Aug 15;335:273-288. Epub 2023 May 17 doi: 10.1016/j.jad.2023.05.041. PMID: 37207946
Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: A Systematic Review and Recommendations of Cannabis use in Bipolar Disorder and Major Depressive Disorder.
Tourjman SV, Buck G, Jutras-Aswad D, Khullar A, McInerney S, Saraf G, Pinto JV, Potvin S, Poulin MJ, Frey BN, Kennedy SH, Lam RW, MacQueen G, Milev R, Parikh SV, Ravindran A, McIntyre RS, Schaffer A, Taylor VH, van Ameringen M, Yatham LN, Beaulieu S
Can J Psychiatry 2023 May;68(5):299-311. Epub 2022 Jun 16 doi: 10.1177/07067437221099769. PMID: 35711159Free PMC Article
Effects of Family-Focused Therapy vs Enhanced Usual Care for Symptomatic Youths at High Risk for Bipolar Disorder: A Randomized Clinical Trial.
Miklowitz DJ, Schneck CD, Walshaw PD, Singh MK, Sullivan AE, Suddath RL, Forgey Borlik M, Sugar CA, Chang KD
JAMA Psychiatry 2020 May 1;77(5):455-463. doi: 10.1001/jamapsychiatry.2019.4520. PMID: 31940011Free PMC Article
Prediction of major depressive disorder onset in college students.
Ebert DD, Buntrock C, Mortier P, Auerbach R, Weisel KK, Kessler RC, Cuijpers P, Green JG, Kiekens G, Nock MK, Demyttenaere K, Bruffaerts R
Depress Anxiety 2019 Apr;36(4):294-304. Epub 2018 Dec 6 doi: 10.1002/da.22867. PMID: 30521136Free PMC Article
Perinatal depression: a systematic review of prevalence and incidence.
Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T
Obstet Gynecol 2005 Nov;106(5 Pt 1):1071-83. doi: 10.1097/01.AOG.0000183597.31630.db. PMID: 16260528

Clinical prediction guides

Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin.
Rosenblat JD, Meshkat S, Doyle Z, Kaczmarek E, Brudner RM, Kratiuk K, Mansur RB, Schulz-Quach C, Sethi R, Abate A, Ali S, Bawks J, Blainey MG, Brietzke E, Cronin V, Danilewitz J, Dhawan S, Di Fonzo A, Di Fonzo M, Drzadzewski P, Dunlop W, Fiszter H, Gomes FA, Grewal S, Leon-Carlyle M, McCallum M, Mofidi N, Offman H, Riva-Cambrin J, Schmidt J, Smolkin M, Quinn JM, Zumrova A, Marlborough M, McIntyre RS
Med 2024 Mar 8;5(3):190-200.e5. Epub 2024 Feb 14 doi: 10.1016/j.medj.2024.01.005. PMID: 38359838
Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression.
Tomasik J, Harrison SJ, Rustogi N, Olmert T, Barton-Owen G, Han SYS, Cooper JD, Eljasz P, Farrag LP, Friend LV, Bell E, Cowell D, Bahn S
JAMA Psychiatry 2024 Jan 1;81(1):101-106. doi: 10.1001/jamapsychiatry.2023.4096. PMID: 37878349Free PMC Article
Blue-Light Therapy for Seasonal and Non-Seasonal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Do A, Li VW, Huang S, Michalak EE, Tam EM, Chakrabarty T, Yatham LN, Lam RW
Can J Psychiatry 2022 Oct;67(10):745-754. Epub 2022 May 6 doi: 10.1177/07067437221097903. PMID: 35522196Free PMC Article
Effects of Family-Focused Therapy vs Enhanced Usual Care for Symptomatic Youths at High Risk for Bipolar Disorder: A Randomized Clinical Trial.
Miklowitz DJ, Schneck CD, Walshaw PD, Singh MK, Sullivan AE, Suddath RL, Forgey Borlik M, Sugar CA, Chang KD
JAMA Psychiatry 2020 May 1;77(5):455-463. doi: 10.1001/jamapsychiatry.2019.4520. PMID: 31940011Free PMC Article
Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank.
Lyall LM, Wyse CA, Graham N, Ferguson A, Lyall DM, Cullen B, Celis Morales CA, Biello SM, Mackay D, Ward J, Strawbridge RJ, Gill JMR, Bailey MES, Pell JP, Smith DJ
Lancet Psychiatry 2018 Jun;5(6):507-514. Epub 2018 May 15 doi: 10.1016/S2215-0366(18)30139-1. PMID: 29776774

Recent systematic reviews

Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis.
Kishi T, Ikuta T, Sakuma K, Okuya M, Hatano M, Matsuda Y, Iwata N
Mol Psychiatry 2023 Jan;28(1):402-409. Epub 2022 Oct 17 doi: 10.1038/s41380-022-01824-z. PMID: 36253442Free PMC Article
Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis.
Ko K, Kopra EI, Cleare AJ, Rucker JJ
J Affect Disord 2023 Feb 1;322:194-204. Epub 2022 Oct 7 doi: 10.1016/j.jad.2022.09.168. PMID: 36209780
Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode: A Systematic Review and Meta-analysis.
Rhee TG, Shim SR, Forester BP, Nierenberg AA, McIntyre RS, Papakostas GI, Krystal JH, Sanacora G, Wilkinson ST
JAMA Psychiatry 2022 Dec 1;79(12):1162-1172. doi: 10.1001/jamapsychiatry.2022.3352. PMID: 36260324Free PMC Article
Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis.
Pearce M, Garcia L, Abbas A, Strain T, Schuch FB, Golubic R, Kelly P, Khan S, Utukuri M, Laird Y, Mok A, Smith A, Tainio M, Brage S, Woodcock J
JAMA Psychiatry 2022 Jun 1;79(6):550-559. doi: 10.1001/jamapsychiatry.2022.0609. PMID: 35416941Free PMC Article
Perinatal depression: a systematic review of prevalence and incidence.
Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T
Obstet Gynecol 2005 Nov;106(5 Pt 1):1071-83. doi: 10.1097/01.AOG.0000183597.31630.db. PMID: 16260528

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

    Consumer resources

    Reviews

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